Vizcarra P, Pérez-Elías MJ, Quereda C, et al. - This observational prospective analysis was undertaken to characterize people (aged ≥18 years) suffering from COVID-19 in a cohort of HIV-infected adults in Madrid. All consecutive HIV-infected people with suspected or verified COVID-19 as of April 30, 2020, were included. Characteristics of HIV-infected patients with COVID-19 were compared with a sample of HIV-infected people evaluated prior to the COVID-19 pandemic. In 51 patients diagnosed with COVID-19, age and CD4 cell counts were found to be similar to those in 1,288 HIV-infected people without; however, the presence of at least one comorbidity (mostly hypertension and diabetes) was detected in 32 (63%) with COVID-19 vs 495 (38%) without COVID-19. A total of 37 (73%) patients had taken tenofovir prior to COVID-19 diagnosis vs 487 (38%) of those without COVID-19; previous protease inhibitor use (mostly darunavir) was reported in 11 (22%) in the COVID-19 group vs 175. Based on the findings, experts recommended not considering HIV-infected persons to be shielded from severe acute respiratory syndrome coronavirus 2 infection or to carry lower risk of severe disease. Generally, these patients should be managed with the same treatment approach applied to the general population.