Solomon DH, et al. - Researchers sought to derive a risk score for major toxicity among nonsteroidal anti-inflammatory drugs (NSAIDs) users enrolled in a randomized controlled trial. They formed derivation and validation cohorts by dividing patients from a randomized controlled trial who had known cardiovascular disease or risk factors, as well as osteoarthritis or rheumatoid arthritis. The derivation cohort yielded significant variables comprising age, male sex, history of cardiovascular disease, hypertension, diabetes mellitus, tobacco use, statin use, elevated serum creatinine level, hematocrit level, and type of arthritis. The validation cohort had C-index of 0.73 and the total cohort had C-index of 0.71. Among NSAID users, the 1-year risk of major toxicity was accurately categorized using the risk score and hence the score may help to identify patients who can safely use these agents.