Solomon DH, et al. - Data were estimated to examine the risk score for major toxicity among non-steroidal anti-inflammatory drugs (NSAIDs) users in this randomized controlled trial. Authors divided the candidates as: with known cardiovascular disease/cardiovascular risk factors who had osteoarthritis or rheumatoid arthritis. Candidates were given celecoxib, naproxen, or ibuprofen at typical dosages randomly. The model was well calibrated with C-index, 0.73 in the validation cohort and 0.71 in the total cohort. They predicted 1080 cases with one-year risk <1%, 16,273 with risks 1-4%, whereas 6382 had predicted risk >4%. They concluded it useful in identifying patients who can safely use these agents.