Grabowska-Fudala B, et al. - Researchers compared the incidence of depressive symptoms in stroke survivors (treated and non-treated) with intravenous thrombolysis, and examined associations between post-stroke depression (PSD) and stroke treatment modalities, accounting for other possible determinants of PSD, like post-traumatic stress symptoms. Although the thrombolysed patients had more severe neurological deficits during the acute phase, thrombolysed and non-thrombolysed stroke survivors had similar incidence of depressive symptoms. After adjustment for other PSD correlates, lack of the recombinant tissue plasminogen activator (rt-PA) treatment was correlated with three-time greater odds of screening for PSD at 3 months post-stroke. Thrombolytic therapy appears to have a positive, if indirect, effect on patients’ mood, particularly in the first months after stroke. Irrespective of the method of treatment, all stroke patients should be monitored for the presence of depression.