Péquignot R, et al. – In the Three-City Study, researchers investigated the magnitude of the association between depressive symptoms at repeated study visits and all-cause and cause-specific mortality. They also investigated the impact of incident cardiovascular disease (CVD) on this association. The study sample consisted of 7,377 adults aged ≥ 65 years without a history of CVD who were examined at baseline 1991-2001, and after 2, 4, 7, and 10 years of follow up. The presence of depressive symptoms was determined upon a score of ≥ 16 on the Center for Epidemiologic Studies Depression Scale at each visit. According to findings, the increased risk of all-cause mortality associated with the presence of depressive symptoms at baseline and during follow-up was not modified by, and was moderately mediated by, incident CVD.