Webers C, et al. - Data from a cross-sectional survey-based multicentre study were used in order to ascertain which factors were related to depressive symptoms in ankylosing spondylitis (AS, a rheumatic disorder resulting in notable impairment in functioning and health) and to understand their underlying associations. Both contextual and disease-related factors were found out to be correlated with depressive symptoms in AS. Mastery, the degree to which one feels in control over life and disease, has a pivotal part in this process. The results strengthen the importance of self-efficiency in disease management and patient education. In order to enhance individuals’ mental health, research is guaranteed whether mastery and its association with depression could be altered.