Marín-Lahoz J, et al. - Researchers conducted this investigation to longitudinally assess the role of depression in the development of impulse control disorders (ICD) in patients with Parkinson disease (PD). Following the Questionnaire for Impulsive-Compulsive Disorders in PD (QUIP), they included PD patients without ICD at baseline using information from the Parkinson Progression Markers Initiative (PPMI). Study participants were prospectively assessed first quarterly and then biannually. At baseline, 68 of 354 patients were depressed. Data reported that the median follows up was 4.08 years. Depression at baseline was linked to higher ICD risk. Findings suggested that depression predisposes ICD in PD to develop. Dopamine agonists magnify this danger. Therefore, dopamine agonists should be used with caution in patients with depressed PD.