Nakano Y, et al. - In this cross-sectional study, researchers investigated the presence and predictors of depression and anxiety in 99 owners of a pet with cancer diagnosis received in the past 1–3 weeks and in 94 owners of a healthy pet. Depression and anxiety were assessed using self-reported questionnaires. Owners of a pet with cancer exhibited significantly higher depression scores than owners of a healthy pet, even after adjustment for potential confounders. Within the owners of a pet with cancer, those who were employed displayed depression significantly more commonly than those who were unemployed. Significantly higher state anxiety scores were noted in owners of a pet with cancer than owners of a healthy pet, even after adjustment for potential confounders, including trait–anxiety scores. Furthermore, among owners of a pet with cancer, owners with high trait anxiety and owners whose pets had a poor prognosis displayed higher state anxiety. This signifies the consideration of inclusion of pet in a family genogram and attention to the pet’s health condition for family practice.