Sneag DB, Zochowski KC, Tan ET, et al. - In this prospective study involving seven healthy volunteers and three peripheral neuropathy patients, researchers assessed principal component analysis (PCA) and generalized spherical deconvolution (genSD) denoising techniques to improve within-subject reproducibility and peripheral nerve conspicuity. Without biasing FA and nerve conspicuity, PCA + genSD denoising method improved signal-to-noise ratio, CNR_FA, and within-subject reproducibility. This technique holds promise to promote peripheral nerve measurements of more precise, unbiased diffusion.