Dutkiewicz R, et al. - Given that retrospective studies indicate cognitive impairment and/or altered levels of Alzheimer Disease (AD)-biomarkers in cerebrospinal fluid (CSF) as mortality predictors in acute hip fracture (AHF)-patients, researchers investigated the truth of this finding in this prospective single-center study with 373 AHF-patients, operated in spinal anesthesia. Clinical Dementia Rating was used to assess cognitive status. AD-biomarker levels (total tau (T-tau), phosphorylated tau, amyloid beta ratio (Aβ42/Aβ40) were analyzed using CSF. Increased 90-day mortality was reported in correlation with high CSF T-tau and low Aβ42/Aβ40-ratio. Based on the findings, experts concluded that increased mortality in these patients can be predicted by cognitive impairment and altered CSF biomarker levels suggestive of AD pathology, and so probably even prior to clinical dementia diagnosis by early biomarker analysis.