Wang X, Chen B, Xu D, et al. - In view of continuously rising incidence and mortality of lung cancer and the fact that cisplatin (DDP) resistance can result in a poor prognosis in lung cancer patients, researchers employed cell counting kit-8 assays, wound healing analyses, Transwell assays, in vitro tumor xenografts, and flow cytometry in order to identify the proliferation, migration, invasion, as well as apoptosis of multidrug resistant A549/DDP and PC9/DDP cells, respectively. According to the findings, reversal of DDP resistance in A549/DDP and PC9/DDP cells can be achieved using delicaflavone which inhibited cell proliferation as well as migration and enhanced apoptosis and cleaved caspase-3 concentrations by raising the expression of CHOP and GRP78 protein via the endoplasmic reticular stress pathway. Experts suggested the likely usefulness of delicaflavone as a treatment adjunct to treat DDP-resistant lung cancer.