Roddy E, et al. - Given the association of antibiotic administration, severity of injury, and debridement with surgical site infection (SSI) after internal fixation of open fractures, researchers here investigated if effect of antibiotic administration is time-dependent among open fracture patients. From an orthopaedic registry from 2013-2017, they assessed data from 230 consecutive open fracture patients; of these, 10% developed a SSI. Patients who did not develop an SSI received antibiotics earlier than those who did develop an SSI. Observations revealed an increased risk of SSI in correlation with administering antibiotics greater than 120 minutes after ED presentation of an open fracture. A 2.4 increased hazard of surgical site infection within 90 days was observed in significant correlation with intravenous antibiotic administration after 120 minutes of presentation of an open fracture to emergency department. .