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Definition of 'close margin' in oral cancer surgery and association of margin distance with local recurrence rate

JAMA Otolaryngology—Head & Neck Surgery Jan 05, 2018

Tasche KK, et al. - Researchers coveted an investigation of the link between specific distances from invasive tumor to surgical margin and local recurrence (LR) in patients with oral cavity squamous cell carcinoma (OCSCC). For speculating local recurrence, an evidential basis was lacking in the commonly used cutoff of 5 mm for a close margin. Despite the absence of any prominent difference for greater distances, a correlation was illustrated in the invasive tumor within 1 mm of the permanent specimen margin with a substantially higher local recurrence rate. The data displayed that a cutoff of less than 1 mm detected patients at increased local recurrence risk who could benefit from additional treatment. For such determination, analysis of the tumor specimen was found to be necessary rather than the tumor bed.
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