Sheppard JP, et al. - Researchers examined the link between arm and leg blood pressure (BP) by analyzing data from all existing studies comparing arm and leg BP measurements in this systematic review, to inform the interpretation of leg BP readings in routine clinical practice where arm readings are not available. MEDLINE and six further databases were searched and studies that measured and reported arm and leg BP taken in the supine position and/or the difference between the two were identified and considered eligible. Screened articles were 887, and those included in the descriptive analyses were 44, with 9771 patients. In the supine position, the general population had ankle SBP 17.0 mmHg higher than arm BP. There was no difference between arm and ankle BP, for DBP. In the ankle vs the arm, SBP which was −33.3 mmHg lower was reported in patients with vascular disease. In routine practice, hypertension could be detected using a diagnostic threshold of 155/90 mmHg in cases where only ankle measurements are available.