Albergotti WG, et al. - Researchers aspired to inspect the prevalence and prognostic importance of perineural invasion (PNI) and angiolymphatic invasion (ALI) in human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC). PNI and ALI were frequently noted in HPV-positive OPSCC, with increasing prevalence as T stage increased. A link was brought to light between the presence of at least 1 risk factor with worse overall and disease-free survival. The presence of ALI or PNI could point towards a poorer prognosis, particularly among patients with stage II disease, classified on the basis of the eighth edition of the American Joint Committee on Cancer (AJCC) manual.