Perlis N, et al. - The goal of this research was to inspect how well the multiparametric MRI (mpMRI) and the PCA3 urine test performed in combination for men with previous biopsies. It was observed that clinically significant Prostate Cancer (PCa) was never detected on biopsy, in patients with dual negative tests (mpMRI and PCA3 score). These could be regarded as unnecessary in this group. This research displayed limitation owing to its retrospective design, selection bias and lack of cost-effectiveness data.