Eshaghi A, et al. - An analysis was performed to examine whether there was a spatiotemporal pattern of grey matter (GM) atrophy that was correlated with faster disability accumulation in multiple sclerosis (MS). Deep GM (DGM) volume loss drove disability accumulation in MS. Temporal cortical GM showed accelerated atrophy in secondary-progressive MS (SPMS) compared to relapsing-remitting MS (RRMS). When evaluating the treatment effect of therapeutic interventions, the difference in regional GM atrophy development between phenotypes needed to be taken into account.