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Deep brain stimulation in the caudal zona incerta vs best medical treatment in patients with Parkinson's disease: A randomised blinded evaluation

Journal of Neurology, Neurosurgery & Psychiatry Feb 03, 2018

Blomstedt P, et al. - Experts intended to assess objectively the effect of caudal zona incerta (cZi) deep brain stimulation (DBS) in patients with Parkinson’s disease (PD). Findings showed the efficacy of cZi DBS on PD symptoms. The most striking effect was on tremor. However, the doses of dopaminergic medications could not be decreased. In PD, cZi DBS could be an addition to existing established targets, enabling tailoring the surgery to the needs of the individual patient.
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