Andiman SE, et al. - A hysterectomy-specific surgical site infection prevention bundle was evaluated for its effect on surgical site infection rate, length of hospital stay, and 30-day postoperative readmission rate. Among 2,099 hysterectomies performed during the 33-month study period, 61 surgical site infections (4.51%) in the pre–full bundle implementation period and 14 (1.87%) in the post–full bundle implementation period were identified. A sustained reduction in the proportion of patients experiencing surgical site infection was noted during the last 8 months of the study period. No statistically significant difference was observed in terms of postoperative days of hospital stay or rate of readmission for surgical site infection-specific indication between the before and after full-bundle implementation periods. Findings thereby suggest that the multidisciplinary implementation of a gynecologic perioperative surgical site infection prevention bundle was efficacious in reducing surgical site infection rate in patients undergoing hysterectomy.