Liu Y, et al. - The SRY-box containing gene 30 (SOX30) is a known cancer-suppressing gene in human pulmonary malignancies, so researchers investigated the molecular role and clinical effects of SOX30 in bladder cancer. They quantified SOX30 mRNA expression in bladder cancer (BC) tissue, paired adjacent normal tissue, and cell lines with real-time quantitative PCR (qRT-PCR) and evaluated SOX30 protein expression in BC tissue and cell lines via western blotting and immunohistochemistry. Findings demonstrate that levels of SOX30 are downregulated in BC cells, which is related to poor prognosis and advanced TNM stage. Furthermore, SOX30 has been identified as a key driver of proliferation, invasion, migration, and apoptosis of BC cells, inferring the tumor suppressive function of SOX30.