Xie M, et al. - Researchers conducted the study for analyzing the role of Sirtuin 1 (Sirt1) in the pathogenesis of ocular Behcet’s disease (OBD). Using enzyme-linked immunosorbent assay (ELISA), Sirt1 and cytokine levels were measured. The frequencies of Th17 and Th22 cells have been detected using flow cytometry. Decreased expression of Sirt1 was observed in CD4 + T cells obtained from active OBD patients. The findings indicate that decreased expression of Sirt1 may be involved in OBD pathogenesis and that Sirt1 activation may be considered a potential target for OBD.