Li X, Chen Y, Xie Y, et al. - Researchers conducted this 8-year prospective study to investigate the pattern of decline and possible determinants of beta-cell function progression in patients with latent-onset autoimmune diabetes in adults (LADA). One hundred six LADA people underwent annual follow-up and their pattern of beta-cell function progression was evaluated. Data reported that the dropout rate was 4.7%. Twenty-nine (28.7%) of the 101 individuals developed beta-cell function failure, defined by fasting C-peptide < 75 pmol/L, during the 8-year follow-up period. The C-peptide decline trend in LADA was biphasic, indicating initial rapid linear progression and then a stable mode followed. C-peptide' decline trend was a fast-followed-by-slow biphasic mode, with around a quarter of LADA patients experiencing beta-cell function failure in the first 8 years. GADA titer less than 173.5 WHO units /mL were suitable for the maintenance of beta-cell function.