Sasaki K, Ravandi F, Kadia TM, et al. - Over the past 4 decades, implementation of several important treatment and supportive care strategies has been done in the management of acute myeloid leukemia (AML). Researchers herein analyzed the outcomes of 29,107 patients who were diagnosed with de novo AML between 1980 and 2017 in the National Cancer Institute's Surveillance, Epidemiology, and End Results database. Categorization of these patients into 5 age groups (ages birth to 14, 15-39, 40-59, 60-69, and ≥ 70 years) and 4 calendar periods (1980-1989, 1990-1999, 2000-2009, and 2010-2017) was done. Data overall suggest incremental improvement in the outcomes of patients with AML over time in this population-based study. The introduction of targeted therapies among older patients since 2017 and optimizations in supportive care are expected to further improve outcomes in AML, particularly among older patients.