DC-SIGN reacts with TLR4 and regulates inflammatory cytokine expression via NF-κB activation in renal tubular epithelial cells during acute renal injury
Clinical and Experimental Immunology Sep 15, 2017
Feng D, et al. - This study was carried out to demonstrate the inflammatory response mechanisms in renal tubular epithelial cells via Toll-like receptor 4 (TLR4) and dendritic cell-specific ICAM-3-grabbing non-integrin 1 (DC-SIGN) signaling. The interactions of DC-SIGN and TLR4 regulated inflammatory responses in renal tubular epithelial cells and participated in acute kidney injury (AKI) pathogenesis.
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