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DASH dietary pattern, mediation by mineral intakes, and the risk of coronary artery disease and stroke mortality

Journal of the American Heart Association Mar 02, 2019

Talaei M, et al. - In Asian populations, researchers assessed the association of the Dietary Approaches to Stop Hypertension (DASH) dietary pattern with stroke and coronary artery disease (CAD) mortality. They also sought to clarify the role of mineral intakes as potential mediators. Data were collected from 57,078 individuals in the Singapore Chinese Health Study (aged 45-74 years at baseline; 1993–1998) for analysis. Using a validated 165-item food frequency questionnaire at recruitment, usual diet was determined, and information on mortality was extracted via registry linkage up to December 31, 2014. Based on quintiles of intake of seven predefined food items and sodium, DASH scores were constructed and hazard ratios and corresponding 95% CIs were computed via Cox proportional hazard models. The investigators noted a substantially lower risk of CAD and stroke mortality in association with adherence to the DASH dietary pattern. No substantial mediation of this inverse association by intakes of sodium, potassium, magnesium, and calcium, however, was evident.

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