Damage to the left uncinate fasciculus is associated with heightened schizotypal traits: A multimodal lesion-mapping study
Schizophrenia Research Mar 09, 2018
Lemaitre AL, et al. - In view of a growing body of evidence that individuals with pronounced schizotypal traits also display particular neurophysiological and morphological features – notably with regard to left frontotemporal connectivity, researchers assessed schizotypal traits in a sample of patients having undergone surgical resection of a diffuse low-grade glioma using the French version of the Schizotypal Personality Questionnaire. The ROI-based lesion-symptom mapping demonstrated a marked association between the cognitive-perceptual (positive) dimension of schizotypy and the left inferior gyrus (including the pars opercularis and the pars orbitalis). Results here suggested heightened positive schizotypal traits in association with dysconnectivity of the neural network supplied by the left uncinate fasciculus.
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