Castro-Rodriguez JA, et al. - In preschoolers with asthma or recurrent wheezing, researchers compared the effectiveness of daily inhaled corticosteroids (ICS) vs leukotriene receptor antagonists (LTRA). For this investigation, they identified randomized, prospective, controlled trials published by December 2017, with a minimum of 3-month therapy with daily ICS vs LTRA. Compared to daily LTRA for improving symptom control and decreasing exacerbations, daily ICS seems more effective, especially in those who need rescue systemic corticosteroids, although the extent of use needs to be quantified. The results from the systematic review indicate that lack of high quality data did not allow firm conclusions on other secondary outcomes.