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Cytomegalovirus viraemia is associated with poor growth and T-cell activation with an increased burden in HIV-exposed uninfected infants

AIDS Aug 11, 2017

Garcia–Knight MA, et al. – In this paper, the prevalence and correlates of cytomegalovirus (CMV) viraemia were described in HIV–exposed–uninfected (HEU) and HIV–unexposed–uninfected (HUU) infants. Authors also quantified its associations with anthropometric, haematological, and immunological outcomes. Findings suggested six–fold greater odds of having CMV viraemia in HEU than HUU infants when adjusted for age. CMV viral load seemed associated with adverse growth and heightened CD8+ T–cell immune activation. They recommend longitudinal assessments of the clinical effects of primary CMV infection and associated immunomodulation in early life in HEU and HUU populations.
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