Tsuprun V, et al. - In the present study, the researchers determined histopathology of the inner ears and the middle ears in human temporal bones with congenital and acquired cytomegalovirus (CMV) infections. By light microscopy, temporal bones from two infants with congenital and two adults with acquired CMV infection were assessed. Data reported that two infants with congenital CMV infection displayed striking pathological changes in the inner ear. In acquired CMV infection, there was no evidence of cytomegalic cells and hair cell loss in the cochlea or vestibular labyrinth. The cochlea, vestibule, and middle ear were highly affected in two infants with congenital CMV infection. Temporal bones of adult donors with acquired viral infection exhibited comparable histological findings without ear disease to donors of the same age.