Steel M, et al. - A total of 22 fine-needle aspirates/biopsies from 14 patients with pancreatic multicystic lesions radiologically suspicious for serous cystadenomata (SCAs, benign pancreatic cystic neoplasms that present a diagnostic difficulty regardless of many investigational strategies), as well as an additional 10 pancreatic resection specimens with confirmed SCA were retrospectively reviewed by the researchers in order to corroborate and build on current evidence which recommended that positive α-inhibin immunohistochemistry (IHC) was a beneficial adjunct in the biopsy confirmation of pancreatic SCA. In the cases with resection confirmed SCA, an α-inhibin IHC sensitivity of 80% was noted. Strongly positive for α-inhibin, 59% of the fine-needle aspirate/biopsy specimens consisted epithelial cells. When selecting for specimens that showed different strips of epithelium, the α-inhibin strong positivity rate progressed to 73%. Vascular endothelial growth factor A values were supportive of false-negative α-inhibin IHC and true-negative α-inhibin IHC in three and one case, respectively. Thus, a diagnostic algorithm to validate pancreatic SCA which may aid in reducing unnecessary follow-up endoscopy/surgical resection and would decline the correlated morbidity, mortality and financial costs in patients with this otherwise benign condition, was postulated.