Gutiérrez FJQ, et al. - Researchers sought to investigate the clinical, morphologic, immunohistochemical, and cytogenetic features of pigmented microcystic chromophobe renal cell carcinoma (PMChRCC), a recently described morphologic variant of ChRCC. In this, probably, largest series of PMCRCC, evidence confirms their low aggressive behavior, with exceptional sarcomatoid transformation and distant metastases. They identified 42 cases in 40 patients in the last 24 years (main age: 60.20 years; 34 males and 6 women) with mean tumor diameter of 4.84 cm (39 intrarenal tumors). Grossly, the tumors were solid with a brown dark colored. Microscopically, pale and eosinophilic cells constituted the tumors, these cells were arranged in microcysts or microalveolar in a cribriform pattern; microcalcifications and a dark brown pigment, mostly extracellular noted. Polysomy of chromosome 7 was noted in 26/36 cases. Thirty-seven patients were alive without disease and two were alive with disease progression at the median follow-up of 74.05 months.