Nasry WHS, et al. - Because cyclooxygenases (COX-1 and COX-2) add to inflammation in oral squamous cell carcinoma (OSCC), and the cluster of differentiation factor 147 (CD147) adds to invasiveness, researchers intended to examine their relationship within a cohort of patients with OSCC or OSCC cell lines. The expression of COX-2 and CD147 was determined on 39 OSCC surgical biopsy specimens using immunohistochemistry. By using a visual grading system, expression in tumor cells, stroma, and adjacent oral epithelium were characterized. According to findings, COX-1, COX-2, and CD147 appear to be regulated independently in the OSCC, representing potentially 2 therapeutic targets for future investigations. COX-1 expression in OSCC deserves further research because PGE2 secretion from OSCC cells may be a significant determinant.