Suzuki S, et al. - Researchers assessed current ventilator management, particularly oxygen management, during general anesthesia in Japan, considering the hypothesis that potentially preventable hyperoxemia and substantial oxygen exposure would be common during general anesthesia. This study included all adult patients (16 yr old or older) who received general anesthesia over 5 consecutive days in 2015 at 43 participating hospitals. These cases were studied focusing on the prevalence of potentially preventable hyperoxemia (oxygen saturation measured by pulse oximetry of more than 98%, despite fractional inspired oxygen tension of more than 0.21) and the risk factors for potentially substantial oxygen exposure (fractional inspired oxygen tension of more than 0.5, despite oxygen saturation measured by pulse oximetry of more than 92%). Findings revealed that during general anesthesia, particularly during one-lung ventilation, potentially preventable hyperoxemia and substantial oxygen exposure were commonly reported.