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Current management and outcome of pregnancies in women with adrenal insufficiency: Experience from a multi-center survey

Journal of Clinical Endocrinology and Metabolism May 23, 2020

Bothou C, Anand G, Li D, et al. - Researchers conducted a multi-center survey on current clinical strategies in managing AI during pregnancy. Analysis of retrospective anonymized data from 19 international centers from 2013-2019 yielded data from 128 pregnancies in 113 women with different causes of AI: Addison disease (44%), secondary AI (25%), congenital adrenal hyperplasia (25%) and acquired AI due to bilateral adrenalectomy (6%). The most commonly used glucocorticoid was hydrocortisone (HC); it was used in 82.9% (97/117) of pregnancies. Increase in glucocorticoid dosage was done at any time during pregnancy in 73/128 (57%) of cases. Fewer cases had increase in fludrocortisone dosage. Women with AI managed in specialized endocrine centers had good maternal and fetal outcome. Reduction in the risk of adrenal crisis and achievement of positive outcomes may likely be due to an emphasis on careful endocrine follow up and repeated patient education.

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