Tian X, Wang A, Wu S, et al. - In this study, the link of cumulative serum uric acid (SUA) (cumSUA) with myocardial infarction (MI) risk as well as with all‐cause mortality was examined, and the impacts of SUA accumulation time course were inquired. Participants were 53,463 individuals without a history of MI, and had undergone 3 examinations during 2006 to 2010. Experts calculated cumSUA from baseline to the third examination, multiplying mean values between consecutive examinations by time intervals between visits. They found higher cumSUA was associated with elevated risk of MI and all‐cause mortality, and SUA accumulation time course also impacted the risk of MI and all‐cause mortality. There was a greater contribution of early SUA accumulation to MI risk and all‐cause mortality when compared with that of later SUA accumulation with the same overall cumulative exposure, highlighting that optimal SUA control early in life is important.