Choi CHR, et al. - This large single-centre study was conducted to test the hypothesis that the risk of colorectal neoplasia (CRN) in ulcerative colitis (UC) closely follows an actuarial accumulative inflammatory burden, which is inadequately represented by current risk stratification strategies. In patients with UC, the risk of CRN was shown to be significantly correlated with the accumulative inflammatory burden. An accurate CRN risk stratification should involve assessment of multiple surveillance episodes to take this into account.