Fang C, Dai J, Zhang S, et al. - Researchers used optical coherence tomography (OCT) to compare culprit lesion features in young vs older age groups of patients with ST-segment elevated myocardial infarction (STEMI). Overall participants were 1,442, who were categorized into the young group (age ≤ 50 years, n = 400) and older group (age > 50 years, n = 1,042). These groups were compared with respect to clinical features, angiography and OCT results. An independent association of age ≤ 50 years with less frequency of plaque rupture, thin cap fibroatheroma, spotty calcification, cholesterol crystals and smaller lumen area stenosis was revealed in multivariate regression analysis. They found that culprit lesion in young STEMI patients exhibited morphological characteristics that were different from those in older patients. More plaque erosion and less vulnerable plaque characteristics were found in patients aged ≤ 50 years.