Pickhardt PJ, et al. - A systematic review and meta-analysis of published CT colonography (CTC) studies assessing lesion detection in senior-age (≥ 65 years old) cohorts was performed. Findings suggested that on average, one in every 12 senior-age adults without symptoms of CRC who underwent screening would be referred to colonoscopy using the 10-mm threshold, with a high yield for advanced neoplasia and high sensitivity for cancer detection. Cohorts of patients 65 years old or older with symptoms of CRC showed higher CTC-positive rates.