Rossi D, et al. - In order to examine the relationship between neurofilament proteins and disease-related variables, the authors measured Neurofilament Light (NF-L) and phosphorylated Heavy (pNF-H) concentrations in the cerebrospinal fluid (CSF) of amyotrophic lateral sclerosis (ALS) patients. In ALS, CSF NF-L and pNF-H were found to represent valuable diagnostic and prognostic biomarkers.