Lind AL, Just D, Mikus M, et al. - Researchers sought for cerebrospinal fluid (CSF) protein profiles that could be potentially associated with fibromyalgia and neuropathic pain. They performed CSF protein profiling of 55 proteins using antibody suspension bead array technology on CSF samples collected from 25 patients with neuropathic pain (two independent sets, n = 14 patients for discovery, and n = 11 for verification), 40 patients with fibromyalgia and 134 controls without neurological disease. CSF of neuropathic pain patients exhibited increased levels of apolipoprotein C1 (APOC1) compared with those in controls and further, fibromyalgia patients showed a trend for increased levels. In addition, the CSF of fibromyalgia patients compared with all other groups including patients with neuropathic pain showed elevated levels of ectonucleotide pyrophosphatase family member 2 (ENPP2, also referred to as autotaxin). These findings may help in assessing the underlying mechanisms of these conditions.