Murray MI, et al. - In patients with paroxysmal atrial fibrillation (pAF) and refractory to antiarrhythmic drug therapy (AAD), the clinical efficacy and safety of cryoballoon (CB) versus traditional irrigated radiofrequency ablation (RF) for pulmonary vein isolation (PVI) was compared via a systemic review, including more than two randomized controlled trials (RCTs) and a meta-analysis. Cryoballoon ablation provided a slightly, non-significant higher freedom from AF 1 year after the ablation and a shorter procedure time and was shown to be an equally effective alternative procedure to the standard radiofrequency treatment.