Mustafa AI, Khashaba RA, Fawzy E, et al. - Researchers conducted the study for exploring the potential connection between oxidative DNA damage and inflammation in alopecia areata (AA) patients through measuring 8‐hydroxy deoxyguanosine (8‐OHdG), high mobility group box 1 protein (HMGB1) and one of the inflammatory mediators; C‐reactive protein (CRP). In total, 79 individuals (49 AA patients in addition to 30 apparently healthy control subjects) were tested for serum levels of 8‐OHdG, HMBG1 and CRP. Serum 8‐OHdG, HMBG1 and CRP levels were significantly elevated in the studied patients group compared with the control group. In addition, logistic regression analysis showed that disease course, serum levels of 8‐OHdG, HMBG1 were considered independent predictors for AA severity in both uni‐ and multi‐variable analyses. The findings indicate that, together with proinflammatory biomarkers, oxidative stress could play a role in the development of AA and its advantage in the prediction of a severe form of the disease.