Jones CC, et al. - In this pleiotropic analysis, researchers assessed cross-cancer pleiotropic associations with lung cancer risk in African Americans. They analyzed 1,410 African American lung cancer patients and 2,843 control participants. A total of 36,958 variants earlier related (or in linkage disequilibrium) to cancer in prior genome-wide association studies were examined. They carried out logistic regression analyses—adjusting for age, sex, global ancestry, study site, and smoking status. Findings revealed newly identified associations on chromosomes 5q14.3, 16q22.2, and 17q12, which carry HNF1B, DHODH, and HAPLN1 genes, respectively. Previously, an association of SNPs within these regions with multiple cancers was reported.