Tang Y, et al. - Because Crohn’s disease (CD) is strongly linked to depression, but the mechanisms underlying this connection are not fully understood, researchers examined monocyte/macrophage phenotypes and plasma cytokine levels in CD. According to the Hospital Anxiety and Depression Scale for depression, eligible CD patients were divided into nondepressed and depressed groups. In CD patients with depressive symptoms, monocytes subpopulation disequilibrium toward intermediate and nonclassic phenotypes and macrophage polarization toward M1 phenotype with increased proinflammatory cytokine release are more likely to occur.