Metwally MA, et al. - In this investigation involving 86 patients, researchers evaluated the diagnostic accuracy of critical flicker frequency (CFF) test for minimal hepatic encephalopathy (MHE), affects 30–55% of patients with liver cirrhosis and can change their daily functions. Study participants included patients with cirrhosis with a negative history of overt hepatic encephalopathy. CFF has been performed for all patients with MHE diagnosis at 39 Hz. MHE patients had significantly older age, jaundice, ascites, reduced hemoglobin level, reduced serum albumin, prolonged INR, higher Child class and score, and higher model of end stage liver disease score than patients without MHE. Among patients with liver cirrhosis, MHE is common. CFF is a simple, rapid, non-invasive MHE diagnostic test with an excellent 39 Hz accuracy.