Helvacıoğlu D, Turan SD, Güran T, et al. - Researchers conducted the study for examining the frequency, long-term outcome and potential predictors of central nervous system (CNS) lesions in a large cohort of girls with central precocious puberty (CPP). Between 2005 and 2017, a multi-center cohort of 770 Turkish girls with CPP underwent a systematic cranial MRI. The average age at puberty onset was < 6 years in 116 and 6-8 years in 654. Although age and the LH/FSH ratio are important predictors of CNS lesions, their predictive power is limited. Thus, despite the low likelihood of finding a lesion requiring intervention, systematic MRI appears to be the most efficient current approach to avoiding missing an occult CNS lesion in girls with CPP.