Chen KH, et al. - The prognostic role of CpG island methylator phenotype (CIMP) in patients with different stages of colorectal cancer (CRC) was investigated via analyzing CIMP in stage I–IV CRC specimens from patients who were diagnosed between 2005 and 2013. Among 450 CRC specimens with successfully determined CIMP statuses, 74 (16.4%) were CIMP-high CRC. Multivariate analysis suggested a CIMP status as an independent prognostic factor for overall mortality in metastatic CRC after adjusting for clinicopathologic variables and anti-cancer therapies. CIMP independently predicts poor OS in patients with stage IV CRC.