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COVID-19-related intracranial imaging findings: A large single-centre experience

Clinical Radiology Oct 07, 2020

Sawlani V, Scotton S, Jacob S, et al. - This study was undertaken to present the neuroradiological changes in patients with coronavirus disease 2019 (COVID-19). Between March 1, 2020 and May 31, 2020, researchers performed a retrospective review of 3,403 patients who were confirmed positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and admitted to Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK, who also had neuroimaging. They assessed abnormal brain imaging in detail and a number of imaging patterns on magnetic resonance imaging MRI were found. A total of 3,403 patients with COVID-19 were included in the study, with 167 (4.9%) having neurological signs or symptoms needing neuroimaging. They observed various imaging patterns on MRI including acute hemorrhagic necrotising encephalopathy, white matter hyperintensities, hypoxic-ischemic changes, ADEM-like changes, and stroke. The most common findings were microhemorrhages. In this patient cohort, prolonged hypoxemia, consumption coagulopathy, and endothelial disruption are the likely pathological drivers and reflect disease severity.

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