Counteracting neuroinflammation in experimental Parkinson’s disease favors recovery of function: Effects of Er-NPCs administration
Journal of Neuroinflammation Dec 05, 2018
Carelli S, et al. - In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) experimental model of Parkinson’s disease (PD), researchers examined the potential anti-inflammatory actions of erythropoietin-releasing neural precursors cells (Er-NPCs) infused. Neuroinflammation measurements of mRNAs of pro-inflammatory and anti-inflammatory cytokines were investigated and immunohistochemistry studies were conducted to evaluate inflammation markers and the potential rescue of tyrosine hydroxylase (TH) projections in the striatum of recipient mice. This investigation reveals the anti-inflammatory actions of Er-NPCs and suggests that these cells can be good candidates for cell therapy to counteract neuroinflammation in neurodegenerative disorders.
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