Idrees JJ, et al. - In order to assess the cost of major complications after liver resection was determined and to determine if high-volume (HV) centers are cost-effective, researchers identified 96,107 cases of liver resection performed in the United States using Nationwide Inpatient Sample from 2002 to 2011 and categorized hospitals as HV (150+ cases/yr), medium-volume (51–149 cases/yr), and low-volume (LV) (1–50 cases/yr) centers. After propensity score matching, the occurrence of a major complication added $33,855 extra cost, increased mean length of stay by 8.7 days and increased risk of death by 9.3%. Compared with LV centers, they identified HV centers as cost-effective at performing the liver resection. Complications such as surgical site infection, respiratory failure, and renal failure after liver resection were identified contributing the most to annual cost burden.